Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16

被引：52

作者：

Rioux, JD

Daly, MJ

Green, T

Stone, V

Lander, ES

Hudson, TJ

Steinhart, AH

Bull, S

Cohen, Z

Greenberg, G

Griffiths, A

McLeod, R

Silverberg, M

Williams, CN

Siminovitch, KA

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] MIT, Whitehead Inst Biomed Res, Ctr Genome Res, Cambridge, MA USA

[3] McGill Univ, Montreal Gen Hosp, Res Inst, Dept Med, Montreal, PQ H3G 1A4, Canada

[4] McGill Univ, Montreal Gen Hosp, Res Inst, Dept Human Genet, Montreal, PQ H3G 1A4, Canada

[5] Univ Toronto, Dept Med, Toronto, ON, Canada

[6] Univ Toronto, Dept Publ Hlth Sci, Toronto, ON, Canada

[7] Univ Toronto, Dept Surg, Toronto, ON, Canada

[8] Univ Toronto, Dept Pediat, Toronto, ON, Canada

[9] Univ Toronto, Dept Immunol & Mol & Med Genet, Toronto, ON, Canada

[10] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[11] Dalhousie Univ, Dept Med, Halifax, NS, Canada

来源：

GASTROENTEROLOGY | 1998年 / 115卷 / 05期

基金：

加拿大自然科学与工程研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0016-5085(98)70074-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: Linkage data derived from genome-wide scans of inflammatory bowel disease (IBD) sibling-pair families have identified 4 loci on chromosomes 3, 7, 12, and 16 as potential sites for IBD susceptibility genes. The aim of this study was to investigate whether linkage analysis of another independently collected set of sibling pairs with IBD would provide further evidence of linkage between these previously reported loci and IBD. Methods: Using the MAPMAKER/SIBS program, the segregation of 21 microsatellite marker loci spanning the 4 putative IBD gene loci was analyzed in a study population comprising 161 families with 114 Crohn's disease, 36 ulcerative colitis, and 50 mixed IBD sibling pairs from the Greater Toronto area. Results: The results of multipoint linkage analysis showed no evidence for linkage between IBD and each of the 21 marker loci studied; the logarithm of odds scores in all instances were less than 0.8. These linkage data were found, by exclusion mapping analysis, to exclude values of hs ranging from 1.5 to 3.0, depending on the locus evaluated. Conclusions: The loci previously suggested as representing IBD susceptibility loci are not linked to IBD in the Toronto population examined in this analysis.

引用

页码：1062 / 1065

页数：4

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