Telomere uncapping and alternative lengthening of telomeres

被引：97

作者：

Cesare, Anthony J. ^{[1
,2
]}

Reddel, Roger R. ^{[1
,2
]}

机构：

[1] Childrens Med Res Inst, Canc Res Unit, Westmead, NSW 2145, Australia

[2] Univ Sydney, Sydney, NSW 2006, Australia

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2008年 / 129卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

alternative lengthening of telomeres; telomere; uncapping; homologous recombination; cellular immortalization;

D O I：

10.1016/j.mad.2007.11.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A substantial number of human tumors utilize a telomerase-independent telomere length maintenance mechanism referred to as alternative lengthening of telomeres (ALT). Although it is known that ALT is a telomere-specific, loss of function phenotype, which involves lengthening of telomeres by homologous recombination-mediated replication of telomeric DNA, many of the details of these processes require elucidation. Here we discuss the current literature on ALT and telomere capping, specifically focusing on how alterations in telomere capping functions may permit activation of ALT and explain the phenotypic characteristics of cells in which this occurs. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：99 / 108

页数：10

共 108 条

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