Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts

被引：134

作者：

Ogasawara, K

Benjamin, J

Takaki, R

Phillips, JH

Lanier, LL ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[3] Int Med Ctr Japan, Res Inst, Div Clin Immunol, Dept Intractable Dis,Shinjuku Ku, Tokyo 1628655, Japan

[4] Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94143 USA

[5] Schering Plough BioPharma, Palo Alto, CA 94304 USA

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 09期

关键词：

D O I：

10.1038/ni1236

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Irradiation- resistant natural killer ( NK) cells in an F-1 recipient can reject parental bone marrow, and host NK cells can also prevent engraftment of allogeneic bone marrow. We show here that repopulating bone marrow cells in certain mouse strains expressed retinoic acid early inducible 1 proteins, which are ligands for the activating NKG2D NK cell receptor. Treatment with a neutralizing antibody to NKG2D prevented rejection of parental BALB/ c bone marrow in ( C57BL/ 6 x BALB/ c) F1 recipients and allowed engraftment of allogeneic BALB. B bone marrow in C57BL/ 6 recipients. Additionally, bone marrow from C57BL/ 6 mice transgenic for retinoic acid early inducible 1 epsilon was rejected by syngeneic mice but was accepted after treatment with antibody to NKG2D. If other stem cells or tissues upregulate expression of NKG2D ligands after transplantation, NKG2D may contribute to graft rejection in immunocompetent hosts.

引用

页码：938 / 945

页数：8

共 40 条

[1] Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells [J].