Trace amines reduce GABAB receptor-mediated presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta

被引：10

作者：

Berretta, N

Giustizieri, M

Bernardi, G

Mercuri, NB

机构：

[1] IRCCS, Fdn Santa Lucia, I-00179 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy

来源：

BRAIN RESEARCH | 2005年 / 1062卷 / 1-2期

关键词：

trace amine; GABAB; substantia nigra; presynaptic mechanism;

D O I：

10.1016/j.brainres.2005.09.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and beta-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABA(B)-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：175 / 178

页数：4

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