Determination of ceftriaxone sodium in pharmaceutical formulations by flow injection analysis with acid potassium permanganate chemiluminescence detection

被引：30

作者：

Zhang, DY

Ma, YJ

Zhou, M

Li, L

Chen, H ^{[1
]}

机构：

[1] NW Normal Univ, Inst Chem, Lanzhou 730070, Peoples R China

[2] Gansu Key Lab Polymer Mat, Lanzhou 730070, Peoples R China

来源：

ANALYTICAL SCIENCES | 2006年 / 22卷 / 01期

关键词：

D O I：

10.2116/analsci.22.183

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Based on the chemiluminescence (CL) emission generated from the oxidation of ceftriaxone sodium alkali hydrolysate by potassium permanganate in polyphosphoric acid (PPA), a novel determination method for ceftriaxone sodium was developed by using a flow-injection technique. The calibration curve appears to be linear in the range between 0.05 and 100 mu g mL(-1) with a detection limit (3 sigma) of 25 ng mL(-1), and a relative standard deviation (RSD) of 0.6% for eleven replicate determinations of 5.0 mu g mL(-1) ceftriaxone sodium. The proposed method has been successfully utilized for the determination of ceftriaxone sodium in pharmaceutical formulations, while the chemiluminescence reaction mechanisms were investigated.

引用

收藏

页码：183 / 186

页数：4

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