Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells

被引：123

作者：

Yang, Xiaoqiang ^{[1
]}

Chen, Yinghua ^{[2
]}

Yuan, Renxu ^{[1
]}

Chen, Guihua ^{[2
]}

Blanco, Elvin ^{[3
]}

Gao, Jinming ^{[3
]}

Shuai, Xintao ^{[1
]}

机构：

[1] Sun Yat Sen Univ, BME Ctr, State Key Lab Optoelect Mat & Technol, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China

[3] Univ Texas SW Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

来源：

POLYMER | 2008年 / 49卷 / 16期

基金：

中国国家自然科学基金;

关键词：

micelles; block copolymers; drug delivery;

D O I：

10.1016/j.polymer.2008.06.005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Diblock copolymers of poly(ethylene glycol) (PEG) and poly(F-caprolactone) (PCL) bearing a tumor-targeting ligand, folate, were self-assembled into micelles. Superparamagnetic iron oxide (SP10) nanoparticles and an anticancer drug doxofubicin (DOX) were coencapsulated within the micelles less than 100 nm in diameters. These SPIO-DOX-loaded micelles were superparamagnetic at room temperature, but turned ferrimagnetic at 10 K, consistent with magnetic properties of primary SPIO nanoparticles. Cell culture experiments demonstrated the potential of these polymeric micelles as an effective dual targeting nanoplatform for the delivery of anticancer drugs. Folate attachment to micelles resulted in the recognition of the micelles by tumor cells over-expressing folate receptors, leading to facilitation in cellular uptake of micelles, and the transport efficiency of the SPIO-loaded and folate-functionalized micelles into the tumor cells can be further enhanced by applying an external magnetic field to the cells. (c) 2008 Elsevier Ltd. All Fights reserved.

引用

页码：3477 / 3485

页数：9

共 30 条

[1] Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes [J].