In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles

被引：163

作者：

Alexiou, C

Jurgons, R

Schmid, R

Hilpert, A

Bergemann, C

Parak, F

Iro, H

机构：

[1] Univ Erlangen Nurnberg, Dept Otorhinolaryngol Head & Neck Surg, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Anat 1, D-91054 Erlangen, Germany

[3] Chemicell GmbH, Berlin, Germany

[4] Tech Univ Munich, Dept Phys, D-8000 Munich, Germany

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期

关键词：

magnetic drug targeting; mitoxantrone; nanoparticles; cancer treatment; chemotherapy; VX2; tumor; ferrofluids; HeLa cells;

D O I：

10.1016/j.jmmm.2005.02.036

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：389 / 393

页数：5

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