Plantazolicin A and B: Structure Elucidation of Ribosomally Synthesized Thiazole/Oxazole Peptides from Bacillus amyloliquefaciens FZB42

被引：82

作者：

Kalyon, Bahar ^{[1
]}

Helaly, Soleiman E. ^{[1
,2
]}

Scholz, Romy ^{[3
]}

Nachtigall, Jonny ^{[1
]}

Vater, Joachim ^{[1
]}

Borriss, Rainer ^{[3
]}

Suessmuth, Roderich D. ^{[1
]}

机构：

[1] Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany

[2] S Valley Univ, Fac Sci, Dept Chem, Aswan 81528, Egypt

[3] Humboldt Univ, Inst Biol Bakteriengenet, D-10115 Berlin, Germany

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 12期

关键词：

FUNCTIONAL-CHARACTERIZATION; BACKBONE MODIFICATIONS; GENE CLUSTERS; BIOSYNTHESIS; SUBTILIS; ANTIBIOTICS; PRODUCT; NMR; OXYDIFFICIDIN; MACROLACTINS;

D O I：

10.1021/ol200809m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures of the ribosomally synthesized peptide antibiotics from Bacillus amyloliquefaciens FZB42, plantazolicin A and B, have teen elucidated by high resolving ESI-MSMS, 2D H-1-C-13-correlated NMR spectroscopy as well as H-1-N-15-HMOCP/H-1-N-15-HMBC NMR experiments. N-15-labeling prior to the experiments facilitated the structure determination, unveiling a hitherto unusual number of thiazoles and oxazoles formed from a linear 14mer precursor peptide. This finding further extends the number of known secondary metabolites from B. amyloliquefaclens and represents a new type of secondary metabolites from the genus Bacillus.

引用

页码：2996 / 2999

页数：4

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