Kinetochore sub-structure comes to MIND

被引：10

作者：

Measday, V

Hieter, P

机构：

[1] Univ British Columbia, Wine Res Ctr, Vancouver, BC V6T 1ZR, Canada

[2] Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1038/ncb0204-94

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The kinetochore attaches the centromeric region of chromosomes to spindle microtubules, allowing equatorial chromosome segregation during mitosis. Proteomic analyses suggest that the kinetochore is a supramolecular complex containing more than 65 proteins that surpasses the size of a ribosome. From within this complex web, stable protein sub-complexes have been extracted, revealing the building blocks for kinetochore assembly.

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页码：94 / 95

页数：2

相关论文

共 12 条

[1] Phospho-regulation of kinetochore-microtubule attachments by the aurora kinase Ipl1p [J].

Cheeseman, LM ;

Anderson, S ;

Jwa, M ;

Green, EM ;

Kang, JS ;

Yates, JR ;

Chan, CSM ;

Drubin, DG ;

Barnes, G .

CELL, 2002, 111 (02) :163-172

[2] Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes [J].

De Wulf, P ;

McAinsh, AD ;

Sorger, PK .

GENES & DEVELOPMENT, 2003, 17 (23) :2902-2921

[3] The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control [J].

Janke, C ;

Ortiz, J ;

Lechner, J ;

Shevchenko, A ;

Shevchenko, A ;

Magiera, MM ;

Schramm, C ;

Schiebel, E .

EMBO JOURNAL, 2001, 20 (04) :777-791

[4]

Le Masson I, 2002, MOL MICROBIOL, V43, P1431

[5] Structure, function, and regulation of budding yeast kinetochores [J].

McAinsh, AD ;

Tytell, JD ;

Sorger, PK .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2003, 19 :519-539

[6] Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore [J].

Measday, V ;

Hailey, DW ;

Pot, I ;

Givan, SA ;

Hyland, KM ;

Cagney, G ;

Fields, S ;

Davis, TN ;

Hieter, P .

GENES & DEVELOPMENT, 2002, 16 (01) :101-113

[7] Interactions between centromere complexes in Saccharomyces cerevisiae [J].

Nekrasov, VS ;

Smith, MA ;

Peak-Chew, S ;

Kilmartin, JV .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (12) :4931-4946

[8] An Mtw1 complex promotes kinetochore biorientation that is monitored by the lpl1/Aurora protein kinase [J].

Pinsky, BA ;

Tatsutani, SY ;

Collins, KA ;

Biggins, S .

DEVELOPMENTAL CELL, 2003, 5 (05) :735-745

[9] Ch14p and Im13p are two new members of the budding yeast outer kinetochore [J].

Pot, I ;

Measday, V ;

Snydsman, B ;

Cagney, G ;

Fields, S ;

Davis, TN ;

Muller, EGD ;

Hieter, P .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (02) :460-476

[10] Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex [J].

Scharfenberger, M ;

Ortiz, J ;

Grau, N ;

Janke, C ;

Schiebel, E ;

Lechner, J .

EMBO JOURNAL, 2003, 22 (24) :6584-6597