Kinetochore sub-structure comes to MIND

被引：10

作者：

Measday, V

Hieter, P

机构：

[1] Univ British Columbia, Wine Res Ctr, Vancouver, BC V6T 1ZR, Canada

[2] Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1038/ncb0204-94

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The kinetochore attaches the centromeric region of chromosomes to spindle microtubules, allowing equatorial chromosome segregation during mitosis. Proteomic analyses suggest that the kinetochore is a supramolecular complex containing more than 65 proteins that surpasses the size of a ribosome. From within this complex web, stable protein sub-complexes have been extracted, revealing the building blocks for kinetochore assembly.

引用

页码：94 / 95

页数：2