Regulation of interleukin-10 and interleukin-22 expression in T helper cells

被引：55

作者：

Rutz, Sascha ^{[1
]}

Ouyang, Wenjun ^{[1
]}

机构：

[1] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 05期

关键词：

ARYL-HYDROCARBON RECEPTOR; GROWTH-FACTOR-BETA; C-MAF; TGF-BETA; CUTTING EDGE; TRANSCRIPTION FACTOR; INTERFERON-GAMMA; IL-10; PRODUCTION; T-H-17; CELLS; TH17;

D O I：

10.1016/j.coi.2011.07.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-10 and IL-22 are crucial regulators of inflammation during immune responses. While IL-10 functions to prevent excessive inflammation by acting on immune cells, IL-22 elicits innate responses from tissue epithelia and promotes wound healing. Although T helper (Th) cells are a major source for both cytokines, IL-10 and IL-22 are rarely coexpressed at high levels in the same cells. Here we discuss a number of common aspects as well as crucial differences in the molecular regulation of both cytokines that might explain their broad, but distinct expression among Th cell subsets.

引用

页码：605 / 612

页数：8

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