The Emerging Role of Smoking in the Development of Pancreatitis

被引：60

作者：

Alexandre, Martine ^{[1
,3
]}

Pandol, Stephen J. ^{[4
,5
]}

Gorelick, Fred S. ^{[1
,2
,3
]}

Thrower, Edwin C. ^{[1
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Sect Digest Dis, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA

[3] Vet Adm Connecticut Healthcare, West Haven, CT USA

[4] Vet Affairs Greater Los Angeles Hlth Care Syst, So Calif Res Ctr Alcohol Liver & Pancreat Dis, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Los Angeles, CA USA

来源：

PANCREATOLOGY | 2011年 / 11卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Acute and chronic pancreatitis; Zymogen activation; Cellular injury; Nicotine; NNK; Tobacco smoking; CIGARETTE-SMOKING; RISK-FACTOR; NICOTINE EXPOSURE; TOBACCO; ADENOCARCINOMA; LUNG; RATS; CELL; INHALATION; ALCOHOL;

D O I：

10.1159/000332196

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background/Aims: Cigarette smoking has been linked to many diseases, including pancreatic cancer and more recently, pancreatitis. Methods: Electronic searches of primarily PubMed from 1990 to August 2011 were conducted and only articles published in English were reviewed. Original articles and reviews were selected based on screening of article abstracts and their relevance to tobacco smoking, its components, nicotine and its metabolites, and their effects particularly on the pancreas. Results: Smoking may affect the risk of developing chronic pancreatitis or its progression. Smoking may also affect the risk for developing acute pancreatitis. Its effects in pancreatitis appear to be dose dependent and its effects may be alcohol independent but synergize with alcohol. Conclusion: Specific constituents of cigarette smoke, including nicotine and its metabolites, could mediate effects on the pancreas. Copyright (C) 2011 S. Karger AG, Basel and IAP

引用

页码：469 / 474

页数：6

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