The mucosal milieu creates tolerogenic dendritic cells and TRI and TH3 regulatory cells

被引：157

作者：

Weiner, HL ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 08期

关键词：

D O I：

10.1038/90604

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Certain types of regulatory T cells are preferentially induced at mucosal surfaces to maintain tolerance. However, the mechanisms involved in their induction are unclear. New evidence suggests DCs orchestrate this mucosal tolerogenic immune response.

引用

页码：671 / 672

页数：2

共 14 条

[1] Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
Akbari, O
DeKruyff, RH
Umetsu, DT
[J]. NATURE IMMUNOLOGY, 2001, 2 (08) : 725 - 731
[2] Dendritic cells and the control of immunity
Banchereau, J
Steinman, RM
[J]. NATURE, 1998, 392 (6673) : 245 - 252
[3] REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS
CHEN, YH
KUCHROO, VK
INOBE, J
HAFLER, DA
WEINER, HL
[J]. SCIENCE, 1994, 265 (5176) : 1237 - 1240
[4] Food for thought - Can immunological tolerance be induced to treat asthma?
Cohn, L
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 24 (05) : 509 - 512
[5] Oral tolerance: Mechanisms and therapeutic applications
Faria, AMC
Weiner, HL
[J]. ADVANCES IN IMMUNOLOGY, VOL 73, 1999, 73 : 153 - 264
[6] A CD4(+) T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Groux, H
OGarra, A
Bigler, M
Rouleau, M
Antonenko, S
deVries, JE
Roncarolo, MG
[J]. NATURE, 1997, 389 (6652) : 737 - 742
[7] Haneda K, 1997, J IMMUNOL, V159, P4484
[8] Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells
Iwasaki, A
Kelsall, BL
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (02) : 229 - 239
[9] Dendritic cell regulation of TH1-TH2 development
Moser, M
Murphy, KM
[J]. NATURE IMMUNOLOGY, 2000, 1 (03) : 199 - 205
[10] SAKAGUCHI S, 1995, J IMMUNOL, V155, P1151

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