Identification of the first retinoid X receptor homodimer antagonist

被引:64
作者
Koch, SSC
Dardashti, LJ
Hebert, JJ
White, SK
Croston, GE
Flatten, KS
Heyman, RA
Nadzan, AM
机构
[1] LIGAND PHARMACEUT INC,DEPT NEW LEADS DISCOVERY,SAN DIEGO,CA 92121
[2] LIGAND PHARMACEUT INC,DEPT ENDOCRINE RES,SAN DIEGO,CA 92121
[3] LIGAND PHARMACEUT INC,DEPT RETINOID RES,SAN DIEGO,CA 92121
关键词
D O I
10.1021/jm960311d
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:3229 / 3234
页数:6
相关论文
共 72 条
[61]   RETINOIC ACID AND THYROID-HORMONE INDUCE GENE-EXPRESSION THROUGH A COMMON RESPONSIVE ELEMENT [J].
UMESONO, K ;
GIGUERE, V ;
GLASS, CK ;
ROSENFELD, MG ;
EVANS, RM .
NATURE, 1988, 336 (6196) :262-265
[62]   DETERMINANTS OF TARGET GENE SPECIFICITY FOR STEROID THYROID-HORMONE RECEPTORS [J].
UMESONO, K ;
EVANS, RM .
CELL, 1989, 57 (07) :1139-1146
[63]   DIRECT REPEATS AS SELECTIVE RESPONSE ELEMENTS FOR THE THYROID-HORMONE, RETINOIC ACID, AND VITAMIN-D3 RECEPTORS [J].
UMESONO, K ;
MURAKAMI, KK ;
THOMPSON, CC ;
EVANS, RM .
CELL, 1991, 65 (07) :1255-1266
[64]   MEDICAL PROGRESS - HEAD AND NECK-CANCER [J].
VOKES, EE ;
WEICHSELBAUM, RR ;
LIPPMAN, SM ;
HONG, WK .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (03) :184-194
[65]   Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere [J].
Vuligonda, V ;
Lin, Y ;
Chandraratna, RAS .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (02) :213-218
[66]   A STRUCTURAL ROLE FOR HORMONE IN THE THYROID-HORMONE RECEPTOR [J].
WAGNER, RL ;
APRILETTI, JW ;
MCGRATH, ME ;
WEST, BL ;
BAXTER, JD ;
FLETTERICK, RJ .
NATURE, 1995, 378 (6558) :690-697
[67]  
WESTMIJZE H, 1978, SYNTHESIS-STUTTGART, V6, P454
[68]   LXR, A NUCLEAR RECEPTOR THAT DEFINES A DISTINCT RETINOID RESPONSE PATHWAY [J].
WILLY, PJ ;
UMESONO, K ;
ONG, ES ;
EVANS, RM ;
HEYMAN, RA ;
MANGELSDORF, DJ .
GENES & DEVELOPMENT, 1995, 9 (09) :1033-1045
[69]   CHARACTERIZATION OF DNA-BINDING AND RETINOIC ACID BINDING-PROPERTIES OF RETINOIC ACID RECEPTOR [J].
YANG, N ;
SCHULE, R ;
MANGELSDORF, DJ ;
EVANS, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3559-3563
[70]   A NOVEL TYPE OF RETINOIC ACID RECEPTOR ANTAGONIST - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF HETEROCYCLIC RING-CONTAINING BENZOIC-ACID DERIVATIVES [J].
YOSHIMURA, H ;
NAGAI, M ;
HIBI, S ;
KIKUCHI, K ;
ABE, S ;
HIDA, T ;
HIGASHI, S ;
HISHINUMA, I ;
YAMANAKA, T .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (16) :3163-3173