Natural paratuberculosis infection in rabbits in Scotland

被引:59
作者
Beard, PM
Rhind, SM
Buxton, D
Daniels, MJ
Henderson, D
Pirie, A
Rudge, K
Greig, A
Hutchings, MR
Stevenson, K
Sharp, JM
机构
[1] Int Res Ctr, Moredun Res Inst, Penicuik EH26 OPZ, Midlothian, Scotland
[2] Univ Edinburgh, Easter Bush Vet Ctr, Dept Vet Pathol, Roslin EH25 9RG, Midlothian, Scotland
[3] Scottish Agr Coll, Anim Biol Div, Edinburgh EH9 3JG, Midlothian, Scotland
[4] Scottish Agr Coll, Vet Sci Div, Perth PH1 1HF, Scotland
关键词
D O I
10.1053/jcpa.2001.0466
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Natural paratuberculosis infection of rabbits (Oryctolagus cuniculus) was recently diagnosed in Scotland, and an investigation into the pathology of the disease in wild rabbits is reported in this paper. Evidence of Mycobacterium avium subsp. paratuberculosis (M.a. paratuberculosis) infection was detected in 22% of 110 rabbits: the organism was cultured from 17 of 110 rabbits, Land histopathological lesions consistent with many. paratuberculosis infection were noted in 18 of 98 rabbits examined. No macroscopical lesions suggestive of M.a. paratuberculosis infection were observed. The histopathological le,ions were either severe or mild. Severe lesions consisted of extensive macrophage granulomata and numerous giant cells, with many intracellular acid-fast bacteria in the small intestine. For the examination formalin-fixed, paraffin wax-embedded tissues, neither immunohistochemistry nor the polymerase chain reaction was as sensitive a method of diagnosis as histopathology. (C) 2001 Harcourt Publishers, Ltd.
引用
收藏
页码:290 / 299
页数:10
相关论文
共 23 条
[11]  
Gyimesi ZS, 1999, J ZOO WILDLIFE MED, V30, P348
[12]   THE HISTOPATHOLOGY OF MYCOBACTERIUM-JOHNEI INFECTION IN SMALL LABORATORY ANIMALS [J].
HARDING, HP .
JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1959, 78 (01) :157-&
[13]  
HIRCH A, 1956, J Comp Pathol, V66, P260, DOI 10.1016/S0368-1742(56)80027-1
[14]   THE EFFECT OF FORMALIN FIXATION ON DNA AND THE EXTRACTION OF HIGH-MOLECULAR-WEIGHT DNA FROM FIXED AND EMBEDDED TISSUES [J].
KOSHIBA, M ;
OGAWA, K ;
HAMAZAKI, S ;
SUGIYAMA, T ;
OGAWA, O ;
KITAJIMA, T .
PATHOLOGY RESEARCH AND PRACTICE, 1993, 189 (01) :66-72
[15]   ISOLATION OF MYCOBACTERIA FROM BROWN HARE (LEPUS-EUROPAEUS) [J].
MATTHEWS, PRJ ;
SARGENT, A .
BRITISH VETERINARY JOURNAL, 1977, 133 (04) :399-404
[16]   A RABBIT MODEL FOR STUDY OF MYCOBACTERIUM-PARATUBERCULOSIS INFECTION [J].
MOKRESH, AH ;
CZUPRYNSKI, CJ ;
BUTLER, DG .
INFECTION AND IMMUNITY, 1989, 57 (12) :3798-3807
[17]  
MOKRESH AH, 1990, CAN J VET RES, V54, P313
[18]   Description and classification of different types of lesion associated with natural paratuberculosis infection in sheep [J].
Perez, V ;
Marin, JFG ;
Badiola, JJ .
JOURNAL OF COMPARATIVE PATHOLOGY, 1996, 114 (02) :107-122
[19]  
Plante Y, 1996, CAN J VET RES, V60, P115
[20]  
*VET LAB AG, 1993, VET INV DIAGN AN REP