Serum Level of IP-10 Increases Predictive Value of IL28B Polymorphisms for Spontaneous Clearance of Acute HCV Infection

被引：87

作者：

Beinhardt, Sandra ^{[1
]}

Aberle, Judith H. ^{[2
]}

Strasser, Michael ^{[3
]}

Dulic-Lakovic, Emina ^{[4
]}

Maieron, Andreas ^{[5
]}

Kreil, Anna ^{[6
]}

Rutter, Karoline ^{[1
]}

Staettermayer, Albert F. ^{[1
]}

Datz, Christian ^{[7
]}

Scherzer, Thomas M. ^{[1
]}

Strassl, Robert ^{[2
]}

Bischof, Martin ^{[8
]}

Stauber, Rudolf ^{[9
]}

Bodlaj, Gerd ^{[10
,11
]}

Laferl, Hermann ^{[12
]}

Holzmann, Heidemarie ^{[2
]}

Steindl-Munda, Petra ^{[1
]}

Ferenci, Peter ^{[1
]}

Hofer, Harald ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Gastroenterol & Hepatol, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Virol, A-1090 Vienna, Austria

[3] Paracelsus Med Univ Salzburg, Salzburg, Austria

[4] Wilhelminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria

[5] Hosp Elisabethinen, Linz, Austria

[6] Otto Wagner Spital, Vienna, Austria

[7] Hosp Oberndorf, Oberndorf, Austria

[8] Hosp Rudolfstiftung, Vienna, Austria

[9] Dept Gastroenterol, Graz, Austria

[10] Med Univ Graz, Graz, Austria

[11] Gen Hosp Linz, Dept Internal Med, Linz, Austria

[12] Kaiser Franz Josef Spital, Dept Internal Med, Vienna, Austria

来源：

GASTROENTEROLOGY | 2012年 / 142卷 / 01期

关键词：

ROC Analysis; Prognostic Factors; Clinical Trial; CXC-L10; ACUTE HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; GENETIC-VARIATION; VIRAL CLEARANCE; VIRUS; THERAPY; GENOTYPE; IMPROVES; IMPACT;

D O I：

10.1053/j.gastro.2011.09.039

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND & AIMS: Single nucleotide polymorphisms (SNPs) in IL28B and serum levels of interferon gamma inducible protein 10 (IP-10) predict outcomes of antiviral therapy in patients with chronic hepatitis C. We associated IL28B SNPs rs12979860 and rs8099917, along with serum levels of IP-10, with outcomes of patients with acute hepatitis C (AHC). METHODS: We studied 120 patients with AHC (64 male; 37 +/- 16 years old) and 96 healthy individuals (controls). The IL28B SNPs rs12979860 and rs8099917 were detected using real-time polymerase chain reaction; serum concentrations of IP-10 were measured by enzyme-linked immunosorbent assays of 62 patients with AHC. RESULTS: Hepatitis C virus was cleared spontaneously from 59 patients (49.2%). The IL28B rs12979860 C/C genotype was more frequent among patients with AHC than controls (62.5% vs 39.6%; P < .001) and among patients with spontaneous clearance than those without (74.6% vs 51.7%; P = .02) (positive predictive value, 60.3%). Patients with IL28B rs12979860 C/C more frequently developed jaundice (53.2% vs 27.6%; P = .022) than carriers of the T allele. The median level of IP-10 was lower among patients with AHC and spontaneous clearance (764 [113-2470] pg/mL) than those without spontaneous clearance (1481 [141-4412] pg/mL; P = .006). Based on receiver operating characteristic analysis, 540 pg/mL IP-10 was set as the cutoff for patients most likely to have spontaneous clearance (positive predictive value, 71.4%; negative predictive value, 65.9%). Including data on IP-10 levels increased the ability of the IL28B rs12979860 C/C to identify patients most likely to have spontaneous clearance (83% of those who had an IP-10 level <540 pg/mL and 32% who had an IP-10 level >540 pg/mL) (P < .01). CONCLUSIONS: The combination of serum level of IP-10 and SNPs in IL28B can identify patients with AHC who are most likely to undergo spontaneous clearance and those in need of early antiviral therapy.

引用

页码：78 / U219

页数：10

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