IL28B and the Control of Hepatitis C Virus Infection

被引：200

作者：

Balagopal, Ashwin ^{[1
]}

Thomas, David L. ^{[1
,2
]}

Thio, Chloe L. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Med, Div Infect Dis, Ctr Viral Hepatitis, Baltimore, MD 21205 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

GASTROENTEROLOGY | 2010年 / 139卷 / 06期

基金：

美国国家卫生研究院;

关键词：

IL28B; Hepatitis C Virus; Interferon Lambda; Interferon Sensitivity; HCV Treatment; GENOME-WIDE ASSOCIATION; GENETIC-VARIATION; INTERFERON-LAMBDA; INTERLEUKIN; 28B; IFN-LAMBDA; GENOTYPE; EXPRESSION; RIBAVIRIN; RESPONSES; THERAPY;

D O I：

10.1053/j.gastro.2010.10.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Treatment-induced control and spontaneous clearance of hepatitis C virus (HCV) infection are affected by various host factors. Polymorphisms in the region of the gene IL28B are associated with HCV clearance, implicating the gene product, interferon (IFN)-lambda 3, in the immune response to HCV. Although it is not clear how the IL28B haplotype affects HCV clearance, IFN-lambda 3 up-regulates interferon-stimulated genes, similar to IFN-alpha and IFN-beta but via a different receptor. There is also evidence that IFN-lambda 3 affects the adaptive immune response. The IL28B genotype can be considered, along with other factors, in predicting patient responses to therapy with pegylated IFN-alpha and ribavirin. We review the genetic studies that uncovered the association between IL28B and HCV clearance, the biology of IFN-lambda 3, the clinical implications of the genetic association, and areas of future research.

引用

页码：1865 / 1876

页数：12

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