IL28B and the Control of Hepatitis C Virus Infection

被引：200

作者：

Balagopal, Ashwin ^{[1
]}

Thomas, David L. ^{[1
,2
]}

Thio, Chloe L. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Med, Div Infect Dis, Ctr Viral Hepatitis, Baltimore, MD 21205 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

GASTROENTEROLOGY | 2010年 / 139卷 / 06期

基金：

美国国家卫生研究院;

关键词：

IL28B; Hepatitis C Virus; Interferon Lambda; Interferon Sensitivity; HCV Treatment; GENOME-WIDE ASSOCIATION; GENETIC-VARIATION; INTERFERON-LAMBDA; INTERLEUKIN; 28B; IFN-LAMBDA; GENOTYPE; EXPRESSION; RIBAVIRIN; RESPONSES; THERAPY;

D O I：

10.1053/j.gastro.2010.10.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Treatment-induced control and spontaneous clearance of hepatitis C virus (HCV) infection are affected by various host factors. Polymorphisms in the region of the gene IL28B are associated with HCV clearance, implicating the gene product, interferon (IFN)-lambda 3, in the immune response to HCV. Although it is not clear how the IL28B haplotype affects HCV clearance, IFN-lambda 3 up-regulates interferon-stimulated genes, similar to IFN-alpha and IFN-beta but via a different receptor. There is also evidence that IFN-lambda 3 affects the adaptive immune response. The IL28B genotype can be considered, along with other factors, in predicting patient responses to therapy with pegylated IFN-alpha and ribavirin. We review the genetic studies that uncovered the association between IL28B and HCV clearance, the biology of IFN-lambda 3, the clinical implications of the genetic association, and areas of future research.

引用

页码：1865 / 1876

页数：12

共 45 条

[31] Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study [J].

Rauch, Andri ;

Kutalik, Zoltan ;

Descombes, Patrick ;

Cai, Tao ;

Di Iulio, Julia ;

Mueller, Tobias ;

Bochud, Murielle ;

Battegay, Manuel ;

Bernasconi, Enos ;

Borovicka, Jan ;

Colombo, Sara ;

Cerny, Andreas ;

Dufour, Jean-Francois ;

Furrer, Hansjakob ;

Guenthard, Huldrych F. ;

Heim, Markus ;

Hirschel, Bernard ;

Malinverni, Raffaele ;

Moradpour, Darius ;

Muellhaupt, Beat ;

Witteck, Andrea ;

Beckmann, Jacques S. ;

Berg, Thomas ;

Bergmann, Sven ;

Negro, Francesco ;

Telenti, Amalio ;

Bochud, Pierre-Yves .

GASTROENTEROLOGY, 2010, 138 (04) :1338-U173

[32] Lambda interferon inhibits hepatitis B and C virus replication [J].

Robek, MD ;

Boyd, BS ;

Chisari, FV .

JOURNAL OF VIROLOGY, 2005, 79 (06) :3851-3854

[33] Interferon signaling and treatment outcome in chronic hepatitis C [J].

Sarasin-Filipowicz, Magdalena ;

Oakeley, Edward J. ;

Duong, Francois H. T. ;

Christen, Verena ;

Terracciano, Luigi ;

Filipowicz, Witold ;

Heim, Markus H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (19) :7034-7039

[34] IFN-lambda (IFN-λ) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo [J].

Sommereyns, Caroline ;

Paul, Sophie ;

Staeheli, Peter ;

Michiels, Thomas .

PLOS PATHOGENS, 2008, 4 (03)

[35] Interferon-λ1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro [J].

Srinivas, Shekar ;

Dai, Jihong ;

Eskdale, Joyce ;

Gallagher, Grant E. ;

Megjugorac, Nicholas J. ;

Gallagher, Grant .

IMMUNOLOGY, 2008, 125 (04) :492-502

[36] IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy [J].

Suppiah, Vijayaprakash ;

Moldovan, Max ;

Ahlenstiel, Golo ;

Berg, Thomas ;

Weltman, Martin ;

Abate, Maria Lorena ;

Bassendine, Margaret ;

Spengler, Ulrich ;

Dore, Gregory J. ;

Powell, Elizabeth ;

Riordan, Stephen ;

Sheridan, David ;

Smedile, Antonina ;

Fragomeli, Vincenzo ;

Mueller, Tobias ;

Bahlo, Melanie ;

Stewart, Graeme J. ;

Booth, David R. ;

George, Jacob .

NATURE GENETICS, 2009, 41 (10) :1100-U74

[37] Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C [J].

Tanaka, Yasuhito ;

Nishida, Nao ;

Sugiyama, Masaya ;

Kurosaki, Masayuki ;

Matsuura, Kentaro ;

Sakamoto, Naoya ;

Nakagawa, Mina ;

Korenaga, Masaaki ;

Hino, Keisuke ;

Hige, Shuhei ;

Ito, Yoshito ;

Mita, Eiji ;

Tanaka, Eiji ;

Mochida, Satoshi ;

Murawaki, Yoshikazu ;

Honda, Masao ;

Sakai, Akito ;

Hiasa, Yoichi ;

Nishiguchi, Shuhei ;

Koike, Asako ;

Sakaida, Isao ;

Imamura, Masatoshi ;

Ito, Kiyoaki ;

Yano, Koji ;

Masaki, Naohiko ;

Sugauchi, Fuminaka ;

Izumi, Namiki ;

Tokunaga, Katsushi ;

Mizokami, Masashi .

NATURE GENETICS, 2009, 41 (10) :1105-U81

[38] Interleukin-28b: A Key Piece of the Hepatitis C Virus Recovery Puzzle [J].

Thio, Chloe L. ;

Thomas, David L. .

GASTROENTEROLOGY, 2010, 138 (04) :1240-1243

[39]

Thomas David L, 2005, Clin Liver Dis, V9, P383, DOI 10.1016/j.cld.2005.05.003

[40] Genetic variation in IL28B and spontaneous clearance of hepatitis C virus [J].

Thomas, David L. ;

Thio, Chloe L. ;

Martin, Maureen P. ;

Qi, Ying ;

Ge, Dongliang ;

O'hUigin, Colm ;

Kidd, Judith ;

Kidd, Kenneth ;

Khakoo, Salim I. ;

Alexander, Graeme ;

Goedert, James J. ;

Kirk, Gregory D. ;

Donfield, Sharyne M. ;

Rosen, Hugo R. ;

Tobler, Leslie H. ;

Busch, Michael P. ;

McHutchison, John G. ;

Goldstein, David B. ;

Carrington, Mary .

NATURE, 2009, 461 (7265) :798-U52

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