The ins and outs of Mycobacterium tuberculosis protein export

被引：66

作者：

Ligon, Lauren S. ^{[1
]}

Hayden, Jennifer D. ^{[1
]}

Braunstein, Miriam ^{[1
]}

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

TUBERCULOSIS | 2012年 / 92卷 / 02期

关键词：

Secretion; Sec; SecA2; Tat; ESX; ARGININE TRANSLOCATION PATHWAY; SEC-INDEPENDENT PROTEIN; ESX-1 SECRETION SYSTEM; ESCHERICHIA-COLI; SIGNAL PEPTIDES; PATHOGENIC MYCOBACTERIA; MEMBRANE-PROTEINS; TRANSPORT-SYSTEM; PREPROTEIN TRANSLOCASE; STAPHYLOCOCCUS-AUREUS;

D O I：

10.1016/j.tube.2011.11.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium tuberculosis is an important pathogen that infects approximately one-third of the world's population and kills almost two million people annually. An important aspect of M. tuberculosis physiology and pathogenesis is its ability to export proteins into and across the thick mycobacterial cell envelope, where they are ideally positioned to interact with the host. In addition to the specific proteins that are exported by M. tuberculosis, the systems through which these proteins are exported represent potential targets for future drug development. M. tuberculosis possesses two well-known and conserved export systems: the housekeeping Sec pathway and the Tat pathway. In addition, M. tuberculosis possesses specialized export systems including the accessory SecA2 pathway and five ESX pathways. Here we review the current understanding of each of these export systems, with a focus on M. tuberculosis, and discuss the contribution of each system to disease and physiology. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：121 / 132

页数：12

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