Exploring HCN channels as novel drug targets

被引：176

作者：

Postea, Otilia ^{[2
]}

Biel, Martin ^{[1
,2
]}

机构：

[1] Univ Munich, Ctr Integrated Prot Sci Munich, D-81377 Munich, Germany

[2] Univ Munich, Ctr Drug Res, Dept Pharm, D-81377 Munich, Germany

来源：

NATURE REVIEWS DRUG DISCOVERY | 2011年 / 10卷 / 12期

关键词：

HYPERPOLARIZATION-ACTIVATED CURRENT; CURRENT I-H; SYSTOLIC DYSFUNCTION BEAUTIFUL; CORONARY-ARTERY-DISEASE; CYCLIC-NUCLEOTIDE; HEART-RATE; PACEMAKER CHANNELS; ION-CHANNEL; SINOATRIAL NODE; CATION CHANNEL;

D O I：

10.1038/nrd3576

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hyperpolarization- activated cyclic nucleotide-gated (HCN) channels have a key role in the control of heart rate and neuronal excitability. Ivabradine is the first compound acting on HCN channels to be clinically approved for the treatment of angina pectoris. HCN channels may offer excellent opportunities for the development of novel anticonvulsant, anaesthetic and analgesic drugs. In support of this idea, some well-established drugs that act on the central nervous system - including lamotrigine, gabapentin and propofol - have been found to modulate HCN channel function. This Review gives an up-to-date summary of compounds acting on HCN channels, and discusses strategies to further explore the potential of these channels for therapeutic intervention.

引用

页码：903 / 914

页数：12

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