The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease

被引：20

作者：

Masson, JY ^{[1
]}

Tremblay, S ^{[1
]}

Ramotar, D ^{[1
]}

机构：

[1] CHUL,RES CTR,HLTH & ENVIRONM UNIT,ST FOY,PQ G1V 4G2,CANADA

来源：

GENE | 1996年 / 179卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Caenorhabditis elegans; CeAPN1; endonuclease; DNA repair;

D O I：

10.1016/S0378-1119(96)00375-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Saccharomyces cerevisiae APN1 gene, encoding the bifunctional DNA repair enzyme apurinic/apyrimidinic (AP) endonuclease/3'-repair diesterase, was used as a probe to isolate a gene homolog, CeAPN1, from a Caenorhabditis elegans cDNA library. The CeAPN1 gene is predicted to encode a protein 30 kDa in size, which shares 40.4% and 44.9% identity at the amino acid level with, respectively, S. cerevisiae Apn1 and Escherichia coli endonuclease IV. We suggest that CeApn1 protein is a member of the endonuclease IV family of DNA repair enzymes.

引用

页码：291 / 293

页数：3

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