Error-prone DNA polymerases: Novel structures and the benefits of infidelity

被引：103

作者：

Friedberg, EC ^{[1
]}

Fischhaber, PL

Kisker, C

机构：

[1] Univ Texas, SW Med Ctr, Dept Pathol, Lab Mol Pathol, Dallas, TX 75390 USA

[2] SUNY Stony Brook, Dept Pharmacol Sci, Ctr Struct Biol, Stony Brook, NY 11794 USA

来源：

CELL | 2001年 / 107卷 / 01期

关键词：

D O I：

10.1016/S0092-8674(01)00509-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

引用

页码：9 / 12

页数：4

共 17 条

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