Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene

被引：279

作者：

Seitz, H

Youngson, N

Lin, SP

Dalbert, S

Paulsen, M

Bachellerie, JP

Ferguson-Smith, AC

Cavaillé, J

机构：

[1] Univ Toulouse 3, LBME, CNRS UMR 5099, IFR 109, F-31062 Toulouse, France

[2] Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England

[3] Univ Saarland, FR Genet, Postfach 151150, D-66041 Saarbrucken, Germany

来源：

NATURE GENETICS | 2003年 / 34卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/ng1171

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are an abundant class of RNAs that are similar to21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.

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页码：261 / 262

页数：2

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