The yin and yang of intestinal epithelial cells in controlling dendritic cell function

被引：67

作者：

Iliev, Iliyan D. ^{[1
]}

Matteoli, Gianluca ^{[1
]}

Rescigno, Maria ^{[1
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2007年 / 204卷 / 10期

关键词：

D O I：

10.1084/jem.20062535

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent work suggests that dendritic cells ( DCs) in mucosal tissues are " educated " by intestinal epithelial cells ( IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, " non- educated " DCs are recruited from nearby areas, such as the dome of Peyer ' s patches ( PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell ( EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs.

引用

页码：2253 / 2257

页数：5

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