A Dual-Emission Forster Resonance Energy Transfer Nanoprobe for Sensing/Imaging pH Changes in the Biological Environment

被引：48

作者：

Chiu, Ya-Ling ^{[1
]}

Chen, Show-An ^{[1
]}

Chen, Jean-Hong ^{[2
]}

Chen, Ko-Jie ^{[1
]}

Chen, Hsin-Lung ^{[1
]}

Sung, Hsing-Wen ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan

[2] Kun Shan Univ, Dept Polymer Mat, Tainan 71003, Taiwan

来源：

ACS NANO | 2010年 / 4卷 / 12期

关键词：

pH-responsive nanoprobe; Forster resonance energy transfer; ratiometric imaging; dual emission; associating polyelectrolyte; nanostructure transformation; IN-VIVO; FRET; CHITOSAN; PEPTIDE; DENDRIMERS; BIOSENSORS; DELIVERY;

D O I：

10.1021/nn102644u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A dual-emission nanoprobe that can sense changes in the environmental pli is designed based on the concept of pH-responsive Forster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chitosan, bearing a donor (Cy3) or an acceptor (Cy5) moiety. We demonstrate that the developed pH-responsive nanoprobe can be used to ratiometrically image and thus discriminate the pH changes In the biological environment at different length scales.

引用

页码：7467 / 7474

页数：8

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