Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex

被引:55
作者
Ghashghaei, H. T. [1 ,2 ,3 ]
Weimer, Jill M. [1 ,2 ]
Schmid, Ralf S. [1 ,2 ,4 ,5 ]
Yokota, Yukako [1 ,2 ]
McCarthy, Ken D. [6 ]
Popko, Brian [7 ]
Anton, E. S. [1 ,2 ]
机构
[1] Univ N Carolina, Ctr Neurosci, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Med, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA
[3] N Carolina State Univ, Sch Vet Med, Dept Mol Biomed Sci, Raleigh, NC 27607 USA
[4] Duke Univ, Ctr Med, Ctr Drug Discovery, Durham, NC 27704 USA
[5] Duke Univ, Ctr Med, Dept Neurobiol, Durham, NC 27704 USA
[6] Univ N Carolina, Sch Med, Dept Pharmacol, Chapel Hill, NC 27599 USA
[7] Univ Chicago, Dept Neurol, Jack Miller Ctr Peripheral Neuropathy, Chicago, IL 60637 USA
关键词
cortical development; neurogenesis; radial glia; ErbB receptors; neuregulins;
D O I
10.1101/gad.1580407
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Radial glial cells play a critical role in the construction of mammalian brain by functioning as a source of new neurons and by providing a scaffold for radial migration of new neurons to their target locations. Radial glia transform into astrocytes at the end of embryonic development. Strategies to promote functional recovery in the injured adult brain depend on the generation of new neurons and the appropriate guidance of these neurons to where they are needed, two critical functions of radial glia. Thus, the competence to regain radial glial identity in the adult brain is of significance for the ability to promote functional repair via neurogenesis and targeted neuronal migration in the mature brain. Here we show that the in vivo induction of the tyrosine kinase receptor, ErbB2, in mature astrocytes enables a subset of them to regain radial glial identity in the mature cerebral cortex. These new radial glial progenitors are capable of giving rise to new neurons and can support neuronal migration. These studies indicate that ErbB2 signaling critically modulates the functional state of radial glia, and induction of ErbB2 in distinct adult astrocytes can promote radial glial identity in the mature cerebral cortex.
引用
收藏
页码:3258 / 3271
页数:14
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