Diabetes Mellitus and Early Age-related Macular Degeneration

被引:45
作者
Choi, Jae Kyung [2 ]
Lym, Youl Lee [2 ]
Moon, Jun Woong [3 ]
Shin, Hyun Jin [3 ]
Cho, Belong [1 ]
机构
[1] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Family Med, Sch Med, Seoul 110744, South Korea
[2] Konkuk Univ, Sch Med, Med Ctr, Dept Family Med,Ctr Hlth Promot, Seoul, South Korea
[3] Konkuk Univ, Sch Med, Med Ctr, Dept Ophthalmol, Seoul, South Korea
关键词
RISK-FACTORS; CARDIOVASCULAR-DISEASE; VISUAL IMPAIRMENT; MACULOPATHY; PATHOGENESIS; ASSOCIATION; SMOKING; BURDEN;
D O I
10.1001/archophthalmol.2010.355
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objective: To examine the association of diabetes mellitus and early age-related macular degeneration (AMD) in Korean adults 50 years and older. Methods: This study included 3008 participants aged 50 to 87 years. Early AMD was assessed from retinal photographs based on a modified Wisconsin AMD grading system. Diabetes mellitus was defined as a fasting glucose level of 126 mg/dL or greater or the use of antidiabetic medications. Logistic regression was used to examine the association between diabetes mellitus and early AMD. Results: There were 88 subjects with early AMD and 315 subjects with diabetes mellitus. After adjusting for age, sex, current smoking, obesity, and hypertension, significant association was found between diabetes mellitus and early AMD. Subjects with diabetes mellitus were more likely to have early AMD (odds ratio, 1.87; 95% confidence interval, 1.07-3.28) than were those without diabetes mellitus. Conclusion: There is a relationship between diabetes mellitus and early AMD in Korean adults 50 years and older. The underlying biological processes remain to be determined.
引用
收藏
页码:196 / 199
页数:4
相关论文
共 28 条
[1]   Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies [J].
Barba, C ;
Cavalli-Sforza, T ;
Cutter, J ;
Darnton-Hill, I ;
Deurenberg, P ;
Deurenberg-Yap, M ;
Gill, T ;
James, P ;
Ko, G ;
Miu, AH ;
Kosulwat, V ;
Kumanyika, S ;
Kurpad, A ;
Mascie-Taylor, N ;
Moon, HK ;
Nishida, C ;
Noor, MI ;
Reddy, KS ;
Rush, E ;
Schultz, JT ;
Seidell, J ;
Stevens, J ;
Swinburn, B ;
Tan, K ;
Weisell, R ;
Wu, ZS ;
Yajnik, CS ;
Yoshiike, N ;
Zimmet, P .
LANCET, 2004, 363 (9403) :157-163
[2]  
Brown Gary C, 2005, Trans Am Ophthalmol Soc, V103, P173
[3]   Smoking and the risk of age-related macular degeneration: A meta-analysis [J].
Cong, Rihong ;
Zhou, Bo ;
Sun, Qingmin ;
Gu, Haijuan ;
Tang, Naping ;
Wang, Bin .
ANNALS OF EPIDEMIOLOGY, 2008, 18 (08) :647-656
[4]  
Congdon N, 2004, ARCH OPHTHALMOL-CHIC, V122, P477
[5]   Burden of illness of neovascular age-related macular degeneration in Canada [J].
Cruess, Alan ;
Zlateva, Gergana ;
Xu, Xiao ;
Rochon, Sophie .
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 2007, 42 (06) :836-843
[6]   The role of inflammation in the pathogenesis of age-related macular degeneration [J].
Donoso, LA ;
Kim, D ;
Frost, A ;
Callahan, A ;
Hageman, G .
SURVEY OF OPHTHALMOLOGY, 2006, 51 (02) :137-152
[7]   Cardiovascular risk factors and age-related macular degeneration: The Los Angeles Latino Eye Study [J].
Fraser-Bell, Samantha ;
Wu, Joanne ;
Klein, Ronald ;
Azen, Stanley P. ;
Hooper, Claire ;
Foong, Athena W. P. ;
Varma, Rohit .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2008, 145 (02) :308-316
[8]   The role of the atherosclerotic process in the pathogenesis of age-related macular degeneration [J].
Friedman, E .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2000, 130 (05) :658-663
[9]  
FRYCZKOWSKI AW, 1988, ANN OPHTHALMOL, V20, P299
[10]   Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report [J].
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, R ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Cleeman, JI ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ ;
Keller, SA ;
Jehle, AJ .
CIRCULATION, 2002, 106 (25) :3143-3421