Cohesin: a global player in chromosome biology with local ties to gene regulation

被引：37

作者：

Merkenschlager, Matthias ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Lymphocyte Dev Grp, London W12 0NN, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 05期

基金：

英国医学研究理事会;

关键词：

SISTER-CHROMATID COHESION; DE-LANGE-SYNDROME; ENHANCER-BLOCKING ACTIVITY; BUDDING YEAST CHROMOSOMES; DOUBLE-STRAND BREAKS; CCCTC-BINDING FACTOR; NIPPED-B; HISTONE MODIFICATION; FISSION YEAST; HUMAN HOMOLOG;

D O I：

10.1016/j.gde.2010.05.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cohesin complexes hold sister chromatids together, which is essential for proper chromosome segregation during cell division and for post-replicative DNA repair. Recent studies suggest that, in addition to this global role in chromosome biology, cohesin is recruited to specific chromosomal locations by CTCF, and perhaps by other sequence-specific DNA binding factors. Once in position, cohesin controls chromosome conformation at the local level. Could this be key to understanding cohesin's role in gene expression?

引用

页码：555 / 561

页数：7

共 69 条

[1]

An epigenetic view of helper T cell differentiation [J].

Ansel, KM ;

Lee, DU ;

Rao, A .

NATURE IMMUNOLOGY, 2003, 4 (07) :616-623

[2]

Long range chromatin interactions involved in gene regulation [J].

Bartkuhn, Marek ;

Renkawitz, Rainer .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (11) :2161-2166

[3]

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators [J].

Bell, AC ;

West, AG ;

Felsenfeld, G .

CELL, 1999, 98 (03) :387-396

[4]

Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion [J].

Ben-Shahar, Tom Rolef ;

Heeger, Sebastian ;

Lehane, Chris ;

East, Philip ;

Flynn, Helen ;

Skehel, Mark ;

Uhlmann, Frank .

SCIENCE, 2008, 321 (5888) :563-566

[5]

Requirement of heterochromatin for cohesion at centromeres [J].

Bernard, P ;

Maure, JF ;

Partridge, JF ;

Genier, S ;

Javerzat, JP ;

Allshire, RC .

SCIENCE, 2001, 294 (5551) :2539-2542

[6]

Boundary elements and nuclear organization [J].

Capelson, M ;

Corces, VG .

BIOLOGY OF THE CELL, 2004, 96 (08) :617-629

[7]

Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins [J].

Ciosk, R ;

Shirayama, M ;

Shevchenko, A ;

Tanaka, TU ;

Toth, A ;

Shevchenko, A ;

Nasmyth, K .

MOLECULAR CELL, 2000, 5 (02) :243-254

[8]

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains [J].

Cuddapah, Suresh ;

Jothi, Raja ;

Schones, Dustin E. ;

Roh, Tae-Young ;

Cui, Kairong ;

Zhao, Keji .

GENOME RESEARCH, 2009, 19 (01) :24-32

[9]

Identification of cis-acting sites for condensin loading onto budding yeast chromosomes [J].

D'Ambrosio, Claudio ;

Schmidt, Christine Katrin ;

Katou, Yuki ;

Kelly, Gavin ;

Itoh, Takehiko ;

Shirahige, Katsuhiko ;

Uhlmann, Frank .

GENES & DEVELOPMENT, 2008, 22 (16) :2215-2227

[10]

Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation [J].

Deardorff, Matthew A. ;

Kaur, Maninder ;

Yaeger, Dinah ;

Rampuria, Abhinav ;

Korolev, Sergey ;

Pie, Juan ;

Gil-Rodriguez, Concepcion ;

Arnedo, Maria ;

Loeys, Bart ;

Kline, Antonie D. ;

Wilson, Meredith ;

Lillquist, Kaj ;

Siu, Victoria ;

Ramos, Feliciano J. ;

Musio, Antonio ;

Jackson, Laird S. ;

Dorsett, Dale ;

Krantz, Ian D. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (03) :485-494

← 1 2 3 4 5 6 7 →