The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus

被引：253

作者：

Hedestam, Gunilla B. Karlsson ^{[2
,3
]}

Fouchier, Ron A. M. ^{[4
,5
]}

Phogat, Sanjay ^{[1
]}

Burton, Dennis R. ^{[6
,7
]}

Sodroski, Joseph ^{[8
]}

Wyatt, Richard T. ^{[1
]}

机构：

[1] NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA

[2] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm 17177, Sweden

[3] Swedish Inst Infect Dis Control, Solna 17182, Sweden

[4] Erasmus MC, Natl Influenza Ctr, NL-3015GE Rotterdam, Netherlands

[5] Erasmus MC, Dept Virol, NL-3015GE Rotterdam, Netherlands

[6] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[7] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[8] Harvard Univ, Sch Med, Div AIDS, Dana Farber Canc Inst,Dept Cancer Immunol & AIDS, Boston, MA 02115 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 02期

关键词：

GP120 ENVELOPE GLYCOPROTEIN; HUMAN MONOCLONAL-ANTIBODY; PROTECTIVE IMMUNITY; RECEPTOR-BINDING; A VIRUS; REVERSE-GENETICS; PROTEOLYTIC CLEAVAGE; GLYCOSYLATION SITES; VACCINE DEVELOPMENT; CD4-BOUND STATE;

D O I：

10.1038/nrmicro1819

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability to elicit broadly neutralizing antibody responses against HIV-1 is a crucial goal for a prophylactic HIV-1 vaccine. Here, we discuss the difficulties of achieving broad HIV-1 neutralization in the context of both the effective annual human influenza virus vaccine and the need to develop a pandemic influenza vaccine. Immunogen-design strategies are underway to target functionally conserved regions of the HIV-1 envelope glycoproteins, and similar strategies might be applicable to pandemic influenza virus vaccine development. Efforts to develop broadly neutralizing vaccines against either HIV-1 or influenza virus might establish a paradigm for future vaccines against highly variable pathogens.

引用

页码：143 / 155

页数：13

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