Immunologic manifestations of autophagy

被引：179

作者：

Deretic, Vojo ^{[1
]}

Kimura, Tomonori ^{[1
]}

Timmins, Graham ^{[2
]}

Moseley, Pope ^{[3
,4
]}

Chauhan, Santosh ^{[1
]}

Mandell, Michael ^{[1
]}

机构：

[1] Univ New Mexico, Hlth Sci Ctr, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

[2] Univ New Mexico, Hlth Sci Ctr, Coll Pharm, Albuquerque, NM 87131 USA

[3] Univ New Mexico, Hlth Sci Ctr, Dept Internal Med, Albuquerque, NM 87131 USA

[4] Univ Copenhagen, Novo Nordisk Fdn, Ctr Prot Res, Copenhagen, Denmark

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2015年 / 125卷 / 01期

关键词：

GENOME-WIDE ASSOCIATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; MHC CLASS-II; MYCOBACTERIUM-TUBERCULOSIS; MITOCHONDRIAL CLEARANCE; SELECTIVE AUTOPHAGY; INHIBITS AUTOPHAGY; REGULATE AUTOPHAGY; GENETIC-VARIANTS; RECEPTOR NDP52;

D O I：

10.1172/JCI73945

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.

引用

页码：75 / 84

页数：10

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