The source of MHC class I presented peptides and its implications

被引：15

作者：

Apcher, Sebastien ^{[1
]}

Martins, Rodrigo Prado ^{[2
]}

Fahraeus, Robin ^{[2
,3
,4
]}

机构：

[1] Univ Paris 11, Inst Gustave Roussy, U1015, Dept Immunol, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[2] Univ Paris 07, Equipe Labellisee Ligue Canc, Inst Genet Mol, Inserm,UMR1162, 27 Rue Juliette Dodu, F-75010 Paris, France

[3] Masaryk Mem Canc Inst, RECAMO, Zluty Kopec 7, Brno 65653, Czech Republic

[4] Umea Univ, Dept Med Biosci, E-90185 Umea, Sweden

来源：

CURRENT OPINION IN IMMUNOLOGY | 2016年 / 40卷

关键词：

MESSENGER-RNA TRANSLATION; CYTOLYTIC T-LYMPHOCYTES; DENDRITIC CELLS; ANTIGENIC PEPTIDES; CROSS-PRESENTATION; MAMMALIAN-CELLS; INTRON SEQUENCE; MAJOR SOURCE; PATHWAY; PROTEIN;

D O I：

10.1016/j.coi.2016.04.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The source of peptides that enter the major histocompatibility class I (MHCI) pathway has been intensively debated over the last two decades. The initial assumption that peptides are derived from degradation of full length proteins was challenged by a model in which alternative translation products are a source of peptides. This model has been tested and supported by scientific data. We now need new hypotheses on the physiological implications of different sources of peptides for the MHCI pathway. The aim of this overview is to give an up-todate account of the source of antigenic peptide material for the MHCI pathway and to incorporate the more recent observations of alternative mRNA translation products into existing models of the direct and cross-presentation pathways.

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收藏

页码：117 / 122

页数：6

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