Liquid chromatography-tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples:: a review

被引：474

作者：

Petrovic, M ^{[1
]}

Hernando, MD ^{[1
]}

Díaz-Cruz, MS ^{[1
]}

Barceló, D ^{[1
]}

机构：

[1] CSIC, IIQAB, Dept Environm Chem, Barcelona 08034, Spain

来源：

JOURNAL OF CHROMATOGRAPHY A | 2005年 / 1067卷 / 1-2期

关键词：

liquid chromatography-tandem mass spectrometry; non-steroidal anti-inflammatory drugs; beta-blockers; antibiotica; lipid regulating agents;

D O I：

10.1016/j.chroma.2004.10.110

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Pharmaceutical residues are environmental contaminants of recent concern and the requirements for analytical methods are mainly dictated by low concentrations found in aqueous and solid environmental samples. In the current article, a review of the liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods published so far for the determination of pharmaceuticals in the environment is presented. Pharmaceuticals included in this review are antibiotics, non-steroidal anti-inflammatory drugs, beta-blockers, lipid regulating agents and psychiatric drugs. Advanced aspects of current LC-MS/MS methodology, including sample preparation and matrix effects, are discussed. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：1 / 14

页数：14

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