Sequence analysis and expression of a novel mouse homolog of Escherichia coli recA gene

被引:20
作者
Kawabata, M [1 ]
Saeki, K [1 ]
机构
[1] Okayama Univ, Sch Med, Dept Pharmacol, Okayama 700, Japan
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1398卷 / 03期
关键词
RecA; RAD51; recombination; repair; brain; (mouse);
D O I
10.1016/S0167-4781(98)00061-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Escherichia coli recA and its yeast homologs RAD51 and DMC1 play crucial roles in mitotic and/or meiotic recombination and in repair of double-strand DNA breaks. We have identified a murine novel recA-like gene (MnTRAD). The predicted amino acid protein showed significant homology to mouse Rec2, Rad51, Dmc1 (or Lim15) and E. coli RecA. Northern blot analysis revealed that MmTRAD was ubiquitously transcribed in various tissues. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:353 / 358
页数:6
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