Reductive coupling of terpenic allylic halides catalyzed by CP2TiCl:: A short and efficient asymmetric synthesis of onocerane triterpenes

被引：54

作者：

Barrero, AF ^{[1
]}

Herrador, MM ^{[1
]}

del Moral, JFQ ^{[1
]}

Arteaga, P ^{[1
]}

Arteaga, JF ^{[1
]}

Piedra, M ^{[1
]}

Sánchez, EM ^{[1
]}

机构：

[1] Univ Granada, Dept Organ Chem, Inst Biotechnol, E-18071 Granada, Spain

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 12期

关键词：

D O I：

10.1021/ol050335r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Titanocene chloride catalyzes the regioselective alpha,alpha '-homocoupling of terpenic allylic halides. This process has been employed in the short and effective synthesis of terpenoids such as beta-onoceradiene (1), beta-onocerin (2), and squalene (3). Evidence is presented for eta(1)-allyltitanium species being involved in the coupling.

引用

页码：2301 / 2304

页数：4

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