Therapeutic potential of stem cells in lung disease: progress and pitfalls

被引:30
作者
Loebinger, Michael R. [1 ]
Aguilar, Susana [1 ]
Janes, Sam M. [1 ]
机构
[1] UCL, Ctr Resp Res, London WC1E 6JJ, England
基金
英国医学研究理事会;
关键词
air-way; bone marrow; gene therapy; lung disease; epithelial cell; progenitor; stem cell;
D O I
10.1042/CS20070073
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
There has been increasing excitement over the last few years with the suggestion that exogenous stem cells may offer new treatment options for a wide range of diseases. Within respiratory medicine, these cells have been shown to have the ability to differentiate and function as both airway and lung parenchyma epithelial cells in both in vitro and increasingly in vivo experiments. The hypothesis is that these cells may actively seek out damaged tissue to assist in the local repair, and the hope is that their use will open up new cellular and genetic treatment modalities. Such is the promise of these cells that they are being rushed from the benchside to the bedside with the commencement of early clinical trials. However, important questions over their use remain and the field is presently littered with controversy and uncertainty. This review evaluates the progress made and the pitfalls encountered to date, and critically assesses the evidence for the use of stem cells in lung disease.
引用
收藏
页码:99 / 108
页数:10
相关论文
共 86 条
[1]   Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung [J].
Aguilar, Susana ;
Nye, Emma ;
Chan, Jerry ;
Loebinger, Michael ;
Spencer-Dene, Bradley ;
Fisk, Nick ;
Stamp, Gordon ;
Bonnet, Dominique ;
Janes, Sam M. .
STEM CELLS, 2007, 25 (06) :1586-1594
[2]   Repopulation of human pulmonary epithelium by bone marrow cells: A potential means to promote repair [J].
Albera, C ;
Polak, JM ;
Janes, S ;
Griffiths, MJD ;
Alison, MR ;
Wright, NA ;
Navaratnarasah, S ;
Poulsom, R ;
Jeffery, R ;
Fisher, C ;
Burke, M ;
Bishop, AE .
TISSUE ENGINEERING, 2005, 11 (7-8) :1115-1121
[3]  
Aldhous P, 2007, NEW SCI, V193, P12
[4]   Derivation of type II alveolar epithelial cells from murine embryonic stem cells [J].
Ali, NN ;
Edgar, AJ ;
Samadikuchaksaraei, A ;
Timson, CM ;
Romanska, HM ;
Polak, JM ;
Bishop, AE .
TISSUE ENGINEERING, 2002, 8 (04) :541-550
[5]   Bone marrow production of lung cells: The impact of G-CSF, cardiotoxin, graded doses of irradiation, and subpopulation phenotype [J].
Aliotta, JM ;
Keaney, P ;
Passero, M ;
Dooner, MS ;
Pimentel, J ;
Greer, D ;
Demers, D ;
Foster, B ;
Peterson, A ;
Dooner, G ;
Theise, ND ;
Abedi, M ;
Colvin, GA ;
Quesenberry, PJ .
EXPERIMENTAL HEMATOLOGY, 2006, 34 (02) :230-241
[6]   CORRELATIVE STUDY OF ADULT RESPIRATORY-DISTRESS SYNDROME BY LIGHT, SCANNING, AND TRANSMISSION ELECTRON-MICROSCOPY [J].
ANDERSON, WR ;
THIELEN, K .
ULTRASTRUCTURAL PATHOLOGY, 1992, 16 (06) :615-628
[7]   In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions [J].
Anjos-Afonso, F ;
Siapati, EK ;
Bonnet, D .
JOURNAL OF CELL SCIENCE, 2004, 117 (23) :5655-5664
[8]   Transcoronary transplantation of progenitor cells after myocardial infarction [J].
Assmus, Birgit ;
Honold, Joerg ;
Schaechinger, Volker ;
Britten, Martina B. ;
Fischer-Rasokat, Ulrich ;
Lehmann, Ralf ;
Teupe, Claudius ;
Pistorius, Katrin ;
Martin, Hans ;
Abolmaali, Nasreddin D. ;
Tonn, Torsten ;
Dimmeler, Stefanie ;
Zeiher, Andreas M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (12) :1222-1232
[9]   Side effects of retroviral gene transfer into hematopoietic stem cells [J].
Baum, C ;
Düllmann, J ;
Li, ZX ;
Fehse, B ;
Meyer, J ;
Williams, DA ;
von Kalle, C .
BLOOD, 2003, 101 (06) :2099-2114
[10]   Biology of human bone marrow stem cells [J].
Bonnet, D .
CLINICAL AND EXPERIMENTAL MEDICINE, 2003, 3 (03) :140-149