Biology of human bone marrow stem cells

被引：63

作者：

Bonnet, D ^{[1
]}

机构：

[1] Canc Res UK, Hematopoiet Stem Cell Lab, London Res Inst, London WC2A 3PX, England

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2003年 / 3卷 / 03期

关键词：

hematopoietic stem cell; mesenchymal stem cell; xenotransplantation model; nonobese diabetic/severe combined immunodeficient mice; fetal sheep; plasticity; transdifferentiation;

D O I：

10.1007/s10238-003-0017-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The bone marrow is constituted of two separate and distinct stem cells. The hematopoietic stem cells (HSC) are responsible for the production and maintenance of all the mature blood cells. The mesenchymal stem cells constituted the bone marrow stroma. In this report we review our current understanding on both stem cell populations. We also discuss the recent unexpected degree of differentiation plasticity that have been reported recently and the impacts these new discoveries may have in stem cell therapy.

引用

页码：140 / 149

页数：10

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