Assessment of functional impairment following permanent middle cerebral artery occlusion in a non-human primate species

被引:55
作者
Marshall, JWB [1 ]
Ridley, RM [1 ]
机构
[1] UNIV CAMBRIDGE,DEPT EXPT PSYCHOL,MRC,COMPARAT COGNIT TEAM,CAMBRIDGE CB2 3EB,ENGLAND
来源
NEURODEGENERATION | 1996年 / 5卷 / 03期
关键词
ischaemia; marmoset; middle cerebral artery; primate; stroke;
D O I
10.1006/neur.1996.0036
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The purpose of the present study was to examine and quantify the functional consequence of a focal cerebral ischaemic lesion in a primate species, the marmoset. Following craniotomy and retraction of the frontal and temporal lobes, the middle cerebral artery was permanently occluded by means of electrocoagulation. Three and eight weeks after surgery, various behavioural tests were used to give a quantifiable measure to the neurological deficits produced. These tests required the monkeys to reach into tubes for foodbits, retrieve rewards from the steps of two designs of 'staircases', respond to one of two simultaneously presented rewarded tubes, remove adhesive labels attached to their feet, and respond to sensory stimuli. Unilateral motor impairment of the contralateral forelimb and neglect of contralateral tactile stimuli were seen in all subjects, and spatial neglect was also present in some monkeys. Subsequent histological analysis revealed unilateral cortical damage in all subjects with varying amounts of injury to the caudate and the putamen in some animals. These results demonstrate the potential for the use of this species in future investigations to examine the effect of neuroprotective treatment on functional outcome after a focal ischaemic insult. (C) 1996 Academic Press Limited
引用
收藏
页码:275 / 286
页数:12
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