ANIMAL-MODELS OF ACUTE ISCHEMIC STROKE - CAN THEY PREDICT CLINICALLY SUCCESSFUL NEUROPROTECTIVE DRUGS

被引：129

作者：

HUNTER, AJ ^{[1
]}

GREEN, AR ^{[1
]}

CROSS, AJ ^{[1
]}

机构：

[1] ASTRA NEUROSCI RES UNIT,LONDON WC1N 1PJ,ENGLAND

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1995年 / 16卷 / 04期

关键词：

D O I：

10.1016/S0165-6147(00)88999-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Substantial efforts are being made to develop drugs which will protect the brain from the neurodegeneration that follows an acute ischaemic stroke. However, while there are already a significant number of animal models of stroke, there is currently no information as to whether activity of a compound in any of them will predict clinical efficacy. In this article, Jackie Hunter, Richard Green and Alan Cross review the major models of acute cerebral ischaemia and propose rational protocols for examining novel neuroprotective agents.

引用

页码：123 / 128

页数：6

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[2]

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[3]

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