Case-control study of the α-synuclein interacting protein gene and Parkinson's disease

被引：14

作者：

Maraganore, DM

Farrer, MJ

Lesnick, TG

de Andrade, M

Bower, JH

Hernandez, D

Hardy, JA

Rocca, WA

机构：

[1] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[4] NIA, Neurogenet Lab, Bethesda, MD 20892 USA

来源：

MOVEMENT DISORDERS | 2003年 / 18卷 / 11期

关键词：

Parkinson's disease; synphilin-1; alphasynuclein; parkin; susceptibility genes; association; interactions; SYNPHILIN-1; GENE; ASSOCIATION; SUSCEPTIBILITY; POLYMORPHISMS; MUTATIONS; HAPLOTYPES; SCREEN;

D O I：

10.1002/mds.10547

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We conducted a case-control study of the alpha-synuclein-interacting protein gene (SNCAIP, also known as synphilin-1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5' terminal of exons 1, 4, and 6. None of the variants were found associated with PD, overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the alpha-synuclein gene (SNCA) or the parkin (PARK2) gene. (C) 2003 Movement Disorder Society.

引用

页码：1233 / 1239

页数：7