An efficient one-pot synthesis of flavones

被引：35

作者：

Chee, Chin Fei ^{[2
]}

Buckle, Michael J. C. ^{[1
]}

Abd Rahman, Noorsaadah ^{[2
]}

机构：

[1] Univ Malaya, Dept Pharm, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 24期

关键词：

CHEMICAL-PROPERTIES; HYDROXYFLAVONES;

D O I：

10.1016/j.tetlet.2011.04.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Flavones were prepared using a one-pot procedure starting from the corresponding 2'-hydroxyacetophenones. The latter were treated with 3 equiv of aroyl chloride in wet K2CO3/acetone (1% w/w water) to afford a good yield of flavone and a smaller amount of 3-aroylflavone. Evidence was obtained that the reaction proceeds via a triketone intermediate. When the reactants were heated in 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and pyridine, the 3-aroylflavone was obtained exclusively. Use of a stoichiometric amount of aroyl chloride afforded only the corresponding flavone. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3120 / 3123

页数：4

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