Gene regulation by patterned electrical activity during neural and skeletal muscle development

被引：117

作者：

Buonanno, A

Fields, RD

机构：

[1] NIH, Mol Neurobiol Unit, Bethesda, MD 20892 USA

[2] NIH, Unit Neurocytol & Physiol, Dev Neurobiol Lab, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1999年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0959-4388(99)80014-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Patterned neural activity modifies central synapses during development and the physiological properties of skeletal muscle by selectively repressing or stimulating transcription of distinct genes. The effects of neural activity are mostly mediated by calcium. Of particular interest are the cellular mechanisms that may be used to sense and convert changes in calcium into specific alterations in gene expression. Recent studies have addressed the importance of spatial heterogeneity or of temporal changes in calcium levels for the regulation of gene expression.

引用

页码：110 / 120

页数：11

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