Increased nitric oxide products in CSF in primary progressive MS may reflect brain atrophy

被引：20

作者：

Peltola, J

Ukkonen, M

Moilanen, E

Elovaara, I

机构：

[1] Tampere Univ Hosp, Dept Neurol, Neuroimmunol Unit, FIN-33521 Tampere, Finland

[2] Univ Tampere, Sch Med, Immunopharmacol Res Grp, FIN-33101 Tampere, Finland

来源：

NEUROLOGY | 2001年 / 57卷 / 05期

关键词：

D O I：

10.1212/WNL.57.5.895

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Because nitric oxide (NO) is a putative mediator of oligodendrocyte damage in the primary progressive form of MS (PPMS), the authors analyzed the levels of NO oxidation products in CSF and plasma from 25 patients with PPMS and 15 controls. The levels of nitrite + nitrate (NOx) in CSF were fourfold higher in patients with PPMS than in controls (p < 0.001), whereas the concentrations in plasma were similar. These data suggests involvement of NO in nervous tissue damage in PPMS.

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收藏

页码：895 / 896

页数：2

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