Human MD-1 homologue is a BCG-regulated gene product in monocytes: Its identification by differential display

被引:13
作者
Begum, NA [1 ]
Tsuji, S
Nomura, R
Shida, K
Azuma, I
Hayashi, A
Matsumoto, M
Seya, T
Toyoshima, K
机构
[1] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Immunol, Higashinari Ku, Osaka 537, Japan
[2] Hokkaido Univ, Inst Immunol Sci, Kita Ku, Sapporo, Hokkaido 060, Japan
[3] Org Pharmaceut Safety & Res, Tokyo 113, Japan
关键词
D O I
10.1006/bbrc.1999.0329
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
BCG-CWS is a thrapeutically potent immune activator which improves the prognosis of cancer patients. However, the targeting effector cells and molecules for BCG-CWS in the human immune system have not been determined. Here, we found that BCG-CWS activates human monocytes and concomitantly down-regulates expression of a human homologue of chicken MD-1 in the activated monocytes by differential display. According to a previous study, MD-1 forms a complex with the Toll family protein RP-105 on murine B cell lines to facilitate its stable expression. Thus, MD-1 may participate in regulation of innate immune activation on human monocytes. Our results, taken together with these recent findings regarding Toll family proteins, suggest that BCG-CWS acts on monocytes to modulate the human innate immune system via regulation of Toll family proteins. (C) 1999 Academic Press.
引用
收藏
页码:325 / 329
页数:5
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