Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

被引：119

作者：

Hezova, Renata ^{[1
]}

Kovarikova, Alena ^{[1
]}

Bienertova-Vasku, Julie ^{[2
]}

Sachlova, Milana ^{[1
]}

Redova, Martina ^{[1
,3
]}

Vasku, Anna ^{[2
]}

Svoboda, Marek ^{[1
]}

Radova, Lenka ^{[4
,5
]}

Kiss, Igor ^{[1
]}

Vyzula, Rostislav ^{[1
]}

Slaby, Ondrej ^{[1
,3
]}

机构：

[1] Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Brno 65653, Czech Republic

[2] Masaryk Univ, Fac Med, Dept Pathol Physiol, Brno 62500, Czech Republic

[3] Masaryk Univ, Cent European Inst Technol, Brno 62500, Czech Republic

[4] Palacky Univ, Fac Med & Dent, Inst Mol & Translat Med, Expt Med Lab, Olomouc 77515, Czech Republic

[5] Palacky Univ, Affiliated Hosp Olomouc, Olomouc 77515, Czech Republic

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2012年 / 18卷 / 22期

关键词：

Association study; Colorectal cancer; MicroRNA; Single nucleotide polymorphism; FUNCTIONAL POLYMORPHISM; GENETIC POLYMORPHISMS; BREAST-CANCER; LUNG-CANCER; SUSCEPTIBILITY; MICRORNAS; VARIANT; ASSOCIATION; EXPRESSION; CARCINOMA;

D O I：

10.3748/wjg.v18.i22.2827

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

AIM: To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes are associated with sporadic colorectal cancer (CRC). METHODS: In order to investigate the effect of these SNPs in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis. RESULTS: The genotype and allele frequencies of SNPs were compared between the cases and the controls. None of the performed analysis showed any statistically significant results. CONCLUSION: Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer. (C) 2012 Baishideng. All rights reserved.

引用

页码：2827 / 2831

页数：5

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