AMP-activated protein kinase-an energy sensor that regulates all aspects of cell function

被引：1304

作者：

Hardie, D. Grahame ^{[1
]}

机构：

[1] Univ Dundee, Div Cell Signalling & Immunol, Coll Life Sci, Dundee DD1 5EH, Scotland

来源：

GENES & DEVELOPMENT | 2011年 / 25卷 / 18期

基金：

英国惠康基金;

关键词：

AMP-activated protein kinase; AMPK; metabolism; autophagy; cell polarity; cell proliferation; FATTY-ACID OXIDATION; HAPLOID INVASIVE GROWTH; TUMOR-SUPPRESSOR LKB1; HMG-COA REDUCTASE; SKELETAL-MUSCLE; SACCHAROMYCES-CEREVISIAE; C-ELEGANS; YEAST SNF1; DIRECT PHOSPHORYLATION; METABOLIC CHECKPOINT;

D O I：

10.1101/gad.17420111

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase is activated by increases not only in AMP, but also in ADP. Although best known for its effects on metabolism, AMPK has many other functions, including regulation of mitochondrial biogenesis and disposal, autophagy, cell polarity, and cell growth and proliferation. Both tumor cells and viruses establish mechanisms to down-regulate AMPK, allowing them to escape its restraining influences on growth.

引用

页码：1895 / 1908

页数：14

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