Protegrins: Structural requirements for inactivating elementary bodies of Chlamydia trachomatis

被引：52

作者：

Yasin, B

Lehrer, RI

Harwig, SSL

Wagar, EA

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT PATHOL & LAB MED, LOS ANGELES, CA 90095 USA

[2] UNIV CALIF LOS ANGELES, SCH MED, DEPT MED, SECT MOL HOST DEF, LOS ANGELES, CA 90095 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 11期

关键词：

D O I：

10.1128/IAI.64.11.4863-4866.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We tested 20 protegrins against Chlamydia trachomatis serovar L2 (L2/434/Bu). Five of the protegrins had native structures; the others included nonamidated, enantiomeric, and truncated variants and peptides with <2 disulfide bonds. Antichlamydial activity resided principally in residues 5 to 15 of native protegrin PG-1, and optimal activity required both intramolecular disulfide bonds.

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页码：4863 / 4866

页数：4

相关论文

共 15 条

[1] HBD-1 - A NOVEL BETA-DEFENSIN FROM HUMAN PLASMA [J].

BENSCH, KW ;

RAIDA, M ;

MAGERT, HJ ;

SCHULZKNAPPE, P ;

FORSSMANN, WG .

FEBS LETTERS, 1995, 368 (02) :331-335

[2]

BEVINS CL, 1994, CIBA F SYMP, V186, P250

[3]

CLARKE LM, 1992, CLIN MICROBIOLOGY PR, V2

[4] TRACHEAL ANTIMICROBIAL PEPTIDE, A CYSTEINE-RICH PEPTIDE FROM MAMMALIAN TRACHEAL MUCOSA - PEPTIDE ISOLATION AND CLONING OF A CDNA [J].

DIAMOND, G ;

ZASLOFF, M ;

ECK, H ;

BRASSEUR, M ;

MALOY, WL ;

BEVINS, CL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3952-3956

[5] ISOLATION OF ANTIMICROBIAL PEPTIDES FROM AVIAN HETEROPHILS [J].

EVANS, EW ;

BEACH, GG ;

WUNDERLICH, J ;

HARMON, BG .

JOURNAL OF LEUKOCYTE BIOLOGY, 1994, 56 (05) :661-665

[6] GALLINACINS - CYSTEINE-RICH ANTIMICROBIAL PEPTIDES OF CHICKEN LEUKOCYTES [J].

HARWIG, SSL ;

SWIDEREK, KM ;

KOKRYAKOV, VN ;

TAN, L ;

LEE, TD ;

PANYUTICH, EA ;

ALESHINA, GM ;

SHAMOVA, OV ;

LEHRER, RI .

FEBS LETTERS, 1994, 342 (03) :281-285

[7] PROTEGRINS - LEUKOCYTE ANTIMICROBIAL PEPTIDES THAT COMBINE FEATURES OF CORTICOSTATIC DEFENSINS AND TACHYPLESINS [J].

KOKRYAKOV, VN ;

HARWIG, SSL ;

PANYUTICH, EA ;

SHEVCHENKO, AA ;

ALESHINA, GM ;

SHAMOVA, OV ;

KORNEVA, HA ;

LEHRER, RI .

FEBS LETTERS, 1993, 327 (02) :231-236

[8]

KUO CC, 1977, NONGONOCOCCAL URETHR, P328

[9] DEFENSINS - ANTIMICROBIAL AND CYTOTOXIC PEPTIDES OF MAMMALIAN-CELLS [J].

LEHRER, RI ;

LICHTENSTEIN, AK ;

GANZ, T .

ANNUAL REVIEW OF IMMUNOLOGY, 1993, 11 :105-128

[10] DEFENSINS AND OTHER ENDOGENOUS PEPTIDE ANTIBIOTICS OF VERTEBRATES [J].

MARTIN, E ;

GANZ, T ;

LEHRER, RI .

JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 58 (02) :128-136