Reaction of pyridine N-oxides with Grignard reagents:: a stereodefined synthesis of substituted dienal oximes

被引：25

作者：

Andersson, Hans

Wang, Xiaoyang

Bjorklund, Mikael

Olsson, Roger

Almqvist, Fredrik ^{[1
]}

机构：

[1] Umea Univ, Dept Chem, SE-90187 Umea, Sweden

[2] ACADIA Pharmaceut AB, S-20512 Malmo, Sweden

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 39期

关键词：

D O I：

10.1016/j.tetlet.2007.07.161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rapid addition of Grignard reagents to pyridine N-oxides under mild conditions gave stereodefined dienal oximes in good to excellent yields. This reaction provides an efficient access to substituted olefins with defined stereochemistry that are potentially of interest as bioactives themselves or as versatile synthetic intermediates. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6941 / 6944

页数：4