RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

被引：2030

作者：

Hersel, U ^{[1
]}

Dahmen, C ^{[1
]}

Kessler, H ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Garching, Germany

来源：

BIOMATERIALS | 2003年 / 24卷 / 24期

关键词：

RGD peptide; integrin; polymer modification; cell attachment; cell behavior; review;

D O I：

10.1016/S0142-9612(03)00343-0

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature 309 (1984) 30), numerous materials have been RGD functionalized for academic studies or medical applications. This review gives an overview of RGD modified polymers, that have been used for cell adhesion, and provides information about technical aspects of RGD immobilization on polymers. The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4385 / 4415

页数：31

共 404 条

[11]

ARNOLD M, UNPUB LATERAL CONTRO

[12]

ART M, 1995, POLYM PREPRINTS, V36, P115

[13] Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations [J].

Aucoin, L ;

Griffith, CM ;

Pleizier, G ;

Deslandes, Y ;

Sheardown, H .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2002, 13 (04) :447-462

[14] ARG-GLY-ASP CONSTRAINED WITHIN CYCLIC PENTAPEPTIDES - STRONG AND SELECTIVE INHIBITORS OF CELL-ADHESION TO VITRONECTIN AND LAMININ FRAGMENT-P1 [J].

AUMAILLEY, M ;

GURRATH, M ;

MULLER, G ;

CALVETE, J ;

TIMPL, R ;

KESSLER, H .

FEBS LETTERS, 1991, 291 (01) :50-54

[15]

Banerjee P, 2000, J BIOMED MATER RES, V50, P331, DOI 10.1002/(SICI)1097-4636(20000605)50:3<331::AID-JBM6>3.3.CO

[16]

2-K

[17] FLUORESCENCE STAINING OF THE ACTIN CYTOSKELETON IN LIVING CELLS WITH 7-NITROBENZ-2-OXA-1,3-DIAZOLE-PHALLACIDIN [J].

BARAK, LS ;

YOCUM, RR ;

NOTHNAGEL, EA ;

WEBB, WW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (02) :980-984

[18] SYNTHESIS AND RGD PEPTIDE MODIFICATION OF A NEW BIODEGRADABLE COPOLYMER - POLY(LACTIC ACID-CO-LYSINE) [J].

BARRERA, DA ;

ZYLSTRA, E ;

LANSBURY, PT ;

LANGER, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (23) :11010-11011

[19] COPOLYMERIZATION AND DEGRADATION OF POLY(LACTIC ACID CO-LYSINE) [J].

BARRERA, DA ;

ZYLSTRA, E ;

LANSBURY, PT ;

LANGER, R .

MACROMOLECULES, 1995, 28 (02) :425-432

[20] Biomolecular modification of p(AAm-co-EG/AA) IPNs supports osteoblast adhesion and phenotypic expression [J].

Bearinger, JP ;

Castner, DG ;

Healy, KE .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1998, 9 (07) :629-652

← 1 2 3 4 5 6 7 8 9 10 →