Triterpenoidal saponins of Pulsatilla koreana roots

被引：47

作者：

Yang, Heejung ^{[1
,2
]}

Cho, Young Woong ^{[1
,2
]}

Kim, Seung Hyun ^{[3
]}

Kim, Young Choong ^{[1
,2
]}

Sung, Sang Hyun ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[3] Elcomsci Co Ltd, Inst Life Sci, Seoul 151742, South Korea

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 16期

关键词：

Pulsatilla koreana Nakai; Ranuculaceae; ESI-MS/MS; Triterpenoidal saponins; Lupane; Oleanane; RAW 264.7 cell line; Nitric oxide; NITRIC-OXIDE PRODUCTION; NF-KAPPA-B; HEDERACOLCHISIDE-E; LUPANE GLYCOSIDES; EXPRESSION; CHINENSIS; LEAVES; LIPOPOLYSACCHARIDE; CONSTITUENTS; MACROPHAGES;

D O I：

10.1016/j.phytochem.2010.07.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Sixteen (1-16) triterpenoidal saponins were isolated from the roots of Pulsatilla koreana, of which four were determined as the previously unknown 23-hydroxy-3 beta-[(O-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid 28-O-beta-D-glucopyranosyl ester (1), 23-hydroxy-3 beta-[(O-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid 28-O-beta-D-glucopyranosyl ester (2), 3 beta-[O-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid 28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (3), and 3 beta-[(O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-[beta-D-glucopyranosyl-(1 -> 4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid 28-O-alpha-L-rhamnopyranosyl-(1 -> 4)-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (4), respectively, based on spectroscopic analysis. The inhibition of the lipopolysaccharide-induced nitric oxide production of sixteen isolated compounds was evaluated in RAW 264.7 cells at concentrations ranging from 1 mu M to 100 mu M. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1892 / 1899

页数：8

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