TLR2 Arg677Trp polymorphism in leprosy: revisited

被引：60

作者：

Malhotra, D ^{[1
]}

Relhan, V ^{[1
]}

Reddy, B ^{[1
]}

Bamezai, R ^{[1
]}

机构：

[1] Lok Nayak Jai Prakash Hosp, Dept Dermatol & Sexually Transmitted Dis, New Delhi, India

来源：

HUMAN GENETICS | 2005年 / 116卷 / 05期

关键词：

D O I：

10.1007/s00439-004-1249-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogate TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls. The case-control comparison also involved investigation of possible variation(s) in the promoter region of the TLR2 gene. Genotyping results after direct PCR sequencing showed that the TLR2 Arg677Trp polymorphism associated with lepromatous leprosy in the Korean population is not a true polymorphism of the TLR2 gene and has resulted from the variation present in the 93% homologous duplicated region of TLR2 exon 3 present approximately 23 kb upstream.

引用

页码：413 / 415

页数：3

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